#1484 Are Girls Treated for Hodgin’s Disease at Higher Risk for Non-Breast Second Malignancies Than Boys. LS Constine, NJ Tarbell, M Hudson, C Schwartz, A Sandhu, RF Raubertas, R Marcus, L Kun, P Mauch, N Mendenhall; University of Rochester Medical Center, Rochester, NY; Massachusetts General Hospital, Boston, MA; St. Jude Children’s Research Hospital, Memphis, TN; The Johns Hopkins Hospital, Baltimore, MD; University of Florida Medical Center, Gainesville, FL, Brigham & Women’s Hospital, Boston, MA. Objective: To ascertain whether sex was predictive for a second malignancy (SMN) following the treatment of pediatric Hodgkin’s Disease (HD). Methods: All 930 children (18 years or younger) treated for HD between 1960 and 1990 at 5 institutions (U. Rochester, Dana Farber, St. Jude, U. Florida, Johns Hopkins U.) were studied. Mean (range) of follow-up was 14.5 years (0.6-37.0). Treatment included radiation therapy (RT) alone (43.3%), chemotherapy (CT) alone (8.9%) or both (CMT) (47.7%). Risk analysis excluded non-melanoma skin and in situ breast cancer. Relative risk (RR) of a SMN was calculated from age-and sex-matched SEER data. Risk factors were evaluated by proportional hazards regression models. Results: Eighty-seven children developed 94 subsequent malignancies: hematologic 15 (AML/ANLL 8, CML 1, NHL 6) and solid 79 (breast 26, soft tissue 12, Gl 11, thyroid 10, melanoma 1, bone 6, H&N 3, CNS 4, pulmonary mesothelioma 2, other 4). The RR for a SMN was 17.0 overall, 25.7 for females and 9.0 for males. Excluding girls with breast cancer, the RR for females was 20.9 (vs. 9.0 for males p=.001). The relationship of therapy to RR was RT 14.4, CT 14.9, CMT 19.9. Seven patients, all girls, had a 3rd malignancy. On multivariate analysis, only female sex (p.001) and increasing time since treatment (p=.047) were significantly associated with risk of SMN. Amount of alkylating agent given was almost significant (p=.068). Effects of treatment variables (mantle dose, RT volume, anthracycline and alkylating agent scores) did not differ significantly between males and females. On univariate analysis, relapse (p=.003) and splenectomy (p=.020) were also significantly associated with SMN. Conclusion: Following treatment for HD, girls are clearly at greater risk for both breast and non-breast SMNs than boys. Persistent longterm increase in risk Excess mortality noted beyond two decades Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.