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Dietary Indole Analogs for Bca Prevention

Dietary Indole Analogs for Breast Cancer Prevention and Abstract #: F-06

Prevention is the best way of dealing with any disease, and this is particularly true of cancer.

We aim to develop potent, orally active cancer preventives by improving upon a dietary component found in cruciferous vegetables such as cabbage, broccoli, and Brussels sprouts, called indole-3-carbinol (I3C), which has known anticancer activity but insufficient potency.

Such diet-based compounds are likely to be safe for long-term use for prevention or to extend disease control. For patients who have been diagnosed with breast cancer, there is an urgent need for new therapies that are more effective than those currently available.

Thus, our aims were expanded to also include preclinical development of our potent indole analogs as breast cancer therapeutics, with the goal of improving the survival rates and quality of life for breast cancer survivors.

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