Assessment of frozen glove use in the prevention of docetaxel induced onycholysis and cutaneous reaction. Results of a multicenter case-control study. F. Scotte, J. M. Tourani, E. Banu, M. Peyromaure, A. Jenabian, E. Levy, K. Coquelin, E. Magherini, S. Marsan, S. Oudard; Georges Pompidou Hospital, Paris, France; Jean Bernard Hospital, Poitiers, France; Cochin Hospital, Paris, France; Aventis France, Paris, France Abstract: Background: Onycholysis and skin toxicity occur in about 15% of patients (pts) treated with docetaxel (D). We investigated the efficacy and safety of an Elasto-Gel (Akromed, France) flexible frozen glove (FG) for the prevention of D-induced onycholysis and skin toxicity. Methods: Cancer pts receiving D at 75 mg/m² (1 hour infusion q3w) alone or in combination chemotherapy were eligible for this matched case-control study. Each patient wore a FG for a total of 90 minutes (min) on the right hand (15 min before, during D administration, and 15 min after). The left hand was not protected by FG and acted the control. Onycholysis and skin toxicity were assessed at each cycle by NCI-CTC v.2 criteria and documented by photography. Wilcoxon matched-pairs ranks test was used to determine the magnitude of difference between two matched groups. Results: Between Aug 2002 and Sept 2003, 45 pts were evaluated: median age 65 years, M/F: 35/10, performance status 0/1/2 (%) = 52/41/7, cancer type (prostate: 58%, lung: 24%, breast: 11%, others: 7%), D monotherapy 72%. Onycholysis and skin toxicity (main criteria) was significantly lower in the FG protected hand compared with the control hand (p=0.0001, Wilcoxon test). Onycholysis was grade (G)0: 89% vs 49% and G1-2: 11% vs 51% in the FG-protected hand and the control hand, respectively. Skin toxicity was G0: 73% vs. 41% and G1-2: 27% vs. 59% in the FG-protected hand and the control hand, respectively. Median time to nail and skin toxicity occurrence was not significantly different between FG-protected and the control hand, respectively [106 days (5 cycles) vs. 58 days (2.7 cycles) for nail toxicity; 57 days vs. 58 days for skin toxicity]. Five pts (11%) experienced discomfort due to cold intolerance of the FG protected hand. Conclusions: Frozen glove significant reduces the nail and skin toxicity associated with docetaxel and provides a new tool in supportive care management for a better patient’s quality of life. Abstract No: 8003 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.