May 2009 reported at the American Academy of Neurology meeting Higher-Than-Expected Leukemia Rates Seen with Mitoxantrone in MS patients Italian multiple sclerosis patients treated with mitoxantrone (Novantrone) developed leukemia at up to 10 times the rate seen in previous studies, researchers reported here. In 2000, it was approved by the FDA for treating multiple sclerosis, including the relapsing-remitting and primary and secondary progressive forms. However, the drug is less popular for these conditions in the U.S. than in Europe, said Dr. Martinelli. In addition to the previously known risk for acute leukemia, the drug is also cardiotoxic and causes neutropenia with an associated risk of infection. It carries a boxed warning about these effects. The study examined records of all patients with multiple sclerosis treated with mitoxantrone since 1999 at the participating hospitals. Inclusion criteria included a minimum of one treatment cycle and one year of follow-up. A total of 2,854 patients were identified, of whom 21 developed acute leukemia, with eight deaths. Martinelli V, et al "Incidence of acute leukemia in multiple sclerosis patients treated with mitoxantrone: a multicenter retrospective study" AAN Abstract LB3.001 Our source: www.medpagetoday.com Leukemia, 12/01 BMD, then Vit D Therapy Stop High-Caffeine Foods, Add Exercise Fruit /Veg intake is Assoc w/Increased Bone Mass Pamidronate & 1,24(S)-dihydroxyvitamin D-2 inhibited growth of cancer cells Journal of Pain and Symptom Management, March 2008 Article in Press, Corrected Proof Walking May Relieve Fatigue in Leukemia Patients www.lef.org January 2008 J Bodywork & Movement Therapies, October, 2001 J Molecular Cancer Thera, 4/03 Cancer (online), 11/06 Cancer Epidem, 6/03 Source: National Institutes of Health (NIH) September, 2004 Childhood Leukemia - Meta-analysis of Proximity Nuclear Facilities AACR Abstract #LB-108, 2003 Various Abstracts from 2003 Frontiers in Cancer Prevention Research AACR Dietary B Vitamins & Lymphoid Cancer Risk:Male Smokers Articles, LINKS Ridiculous article on Diffuse large-B-cell Chinese Medicine & Malignant Lymphoma Increased Morbidity/Mortality & Involved Field RTx Fatigue in Long-term Survivors of Hodgkin's Lymphoma Lymphoma & Psoriasis Hepatitis C Virus & Risk of Non-Hodgkin's Lymphoma Non-Hodgkin's L & Type of Tobacco Smoke Chlamadyiae & Ocular Lymphoma Related Hodgkin Lymphoma & Multiple Sclerosis Subclinical Late Cardio Problems w/Doxorubicin: Lymphoma Excess Risk of Ovarian Ca & Lymphoma Non-Hodgkin's Lymphoma in Asthmatics Exposed to Pesticides NCI Creates Model to Predict Follicular Lymphoma Survival Methotrxate Linked to Lymphomas Vegetable Nutrients Lower Risk: Non-Hodgkin Lymphoma Complete Remission in Relapsed Follicular Lymphoma Pts Various studies, articles links, etc. Boswellic Acid Acetate Kills Ca Cells (in vitro) Chinese Herb contains Flavinoid -Cancer Fighter Effect of Aplidin (Marine substance) in ALL cells Resveratrol as Inducer of Apoptosis(Cell Death) Bovine Lactoferricin Kills Cancer Cells (in vitro) VEGF Receptor & Green Tea: CLL Coriolus versicolor extract & human leukemia xenografts Oridonin Inhibits Lymphoid Ca Cells(Rabdosia rubescens) Piplartine induces inhibition of leukemia cell Cannabidiol-induced apoptosis in human leukemia cells Flavonoid compound kills leukemia cells Pot Compound Enhances Efficacy Of Anti-Cancer Agents Clin Infect Diseases, 2/04 JAMA, 5/04 Lancet Oncol, 7/04 University of Alabama, Birmingham, 5/05 LINKS to various organizations Environmental Toxicology and Pharmacology January 2008 Cancer Cell, 11/05 Am Soc of Hematology, 12/03 Lancet, July 2007 ASCO 2006 Am J Respir Crit Care Med, 11/07 International Journal of Hyperthermia, January 2008 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.