Management and clinical outcomes of pregnant patients with invasive cervical cancer N. Germann1, C. Haie-Meder1,*, P. Morice2, C. Lhomme3, P. Duvillard4, K. Hacene5 and A. Gerbaulet1 Departments of 1 radiothérapie et de curiethérapie, 2 chirurgie gynécologique, 3 oncologie gynécologique and 4 anatomopathologie, Institut Gustave Roussy, Villejuif; 5 Department of Statistics, Centre René Huguenin, Saint-Cloud, France * Correspondence to: Dr C. Haie-Meder, Department of radiothérapie et de curiethérapie, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94 805 Villejuif, France. Tel: +33-1-42-11-45-69; Fax: +33-1-42-11-52-08; Email: haie@igr.fr Background: The objective of this study was to evaluate the clinical outcomes and to discuss the management of women presenting with an invasive cervical cancer during pregnancy. Patients and methods: We retrospectively reviewed patients treated for an invasive cervical cancer diagnosed during pregnancy between 1985 and 2000 in our institution. Results: Twenty-one pregnant patients among a total of 487 women were treated. Thirteen, five, two and one, respectively, were diagnosed during the first, second and third pregnancy trimester and post-partum. The FIGO stage was IB in 15 cases, IIB in five cases and IVA in one case. Mean follow-up was 64 months (range 2–165). Overall and disease-free survival at 5 years were 82% and 79%, respectively. All five patients diagnosed in the second trimester were alive. Two of the 13 patients and one of the two patients diagnosed during the first trimester and the third trimester, respectively, died of their disease. No difference was observed between the nine patients whose treatment was delayed or not. Conclusions: Invasive cervical cancer during pregnancy is rare but is a dilemma for women and their physicians. The present study and review of the literature suggest that pregnancy does not seem to influence the prognosis of cervical cancer. Delayed treatment could be proposed to selected patients diagnosed at the end of the second trimester or at the beginning of the third trimester, with a small tumor (<2 cm) and negative nodes, after a multidisciplinary approach. Annals of Oncology Advance Access originally published online on January 24, 2005 Annals of Oncology 2005 16(3):397-402; doi:10.1093/annonc/mdi084 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.