Original Article The cancer screening practices of adult survivors of childhood cancer A report from the Childhood Cancer Survivor Study Mark W. Yeazel, M.D., M.P.H. 1 *, Kevin C. Oeffinger, M.D. 2, James G. Gurney, Ph.D. 3, Ann C. Mertens, Ph.D. 3, Melissa M. Hudson, M.D. 4, Karen M. Emmons, Ph.D. 5, Hegang Chen, Ph.D. 6, Leslie L. Robison, Ph.D. 3 1Department of Family Practice and Community Health, University of Minnesota Medical School, Minneapolis, Minnesota 2Department of Family Practice and Community Medicine, University of Texas, Southwestern Medical Center at Dallas, Texas 3Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 4Department of Hematology Oncology, St. Jude Children's Research Hospital and University of Tennessee College of Medicine, Memphis, Tennessee 5Division of Community-Based Research, Dana Farber Cancer Institute and Harvard School of Public Health, Boston, Massachusetts 6Department of Biostatics and Bioinformatics, University of Maryland School of Medicine, College Park, Maryland email: Mark W. Yeazel (yeazel@umn.edu) *Correspondence to Mark W. Yeazel, Department of Family Practice and Community Health, University of Minnesota Medical School, Mayo Medical Code 381, 420 Delaware Street S.E., Minneapolis, MN 55455 The following are Childhood Cancer Survivor Study (CCSS) Institutions and Investigators: University of California, San Francisco, CA (Clinical center contributing cases) (Arthur Ablin, M.D. [Institutional Principal Investigator]); University of Alabama, Birmingham, AL (Clinical center contributing cases) (Roger Berkow, M.D. [Institutional Principal Investigator]); International Epidemiology Institute, Rockville, MD (John D. Boice, Jr., Sc.D. [Member CCSS Steering Committee]); University of Washington, Seattle, WA (Norman Breslow, Ph.D. [Institutional Principal Investigator]); University of Texas-Southwestern Medical Center at Dallas, TX (Clinical center contributing cases) (George R. Buchanan, M.D. [Institutional Principal Investigator]); Dana-Farber Cancer Institute, Boston, MA (Clinical center contributing cases) (Lisa Diller, M.D. [Institutional Principal Investigator], Holcombe Grier, M.D. [Former Institutional Principal Investigator], and Frederick Li, M.D. [Member CCSS Steering Committee]); Texas Children's Center, Houston, TX (Clinical center contributing cases) (Zoann Dreyer, M.D. [Institutional Principal Investigator]); Children's Hospital and Medical Center, Seattle, WA (Clinical center contributing cases) (Debra Friedman, M.D., M.P.H. [Institutional Principal Investigator] and Thomas Pendergrass, M.D. [Former Institutional Principal Investigator]); Roswell Park Cancer Institute, Buffalo, NY (Clinical center contributing cases) (Daniel M. Green, M.D. [Institutional Principal Investigator and Member of the CCSS Steering Committee]); Hospital for Sick Children, Toronto, ON (Clinical center contributing cases) (Mark Greenberg, M.B., Ch.B. [Institutional Principal Investigator]); St. Louis Children's Hospital, St. Louis, MO (Clinical center contributing cases) (Robert Hayasyhi, M.D. [Institutional Principal Investigator] and Teresa Vietti, M.D. [Former Institutional Principal Investigator]); St. Jude Children's Research Hospital, Memphis, TN (Clinical center contributing cases) (Melissa Hudson, M.D. [Institutional Principal Investigator and Member of the CCSS Steering Committee]); University of Michigan, Ann Arbor, MI (Clinical center contributing cases) Raymond Hutchinson, M.D. [Institutional Principal Investigator]); Stanford University School of Medicine, Stanford, CA (Clinical center contributing cases) (Michael P. Link, M.D. [Institutional Principal Investigator] and Sarah S. Donaldson, M.D. [Member of the CCSS Steering Committee]; Children's Hospital of Philadelphia, PA (Clinical center contributing cases) (Anna Meadows, M.D. [Institutional Principal Investigator and Member of the CCSS Steering Committee] and Bobbie Bayton [Member of the CCSS Steering Committee]); Children's Hospital, Oklahoma City, OK (John Mulvihill, M.D. [Member of the CCSS Steering Committee]); Children's Hospital, Denver, CO (Clinical center contributing cases) (Brian Greffe, M.D. [Institutional Principal Investigator] and Lorrie Odom, M.D. [Former Institutional Principal Investigator]); Children's Health Care-Minneapolis, MN (Clinical center contributing cases) (Maura O'Leary, M.D. [Institutional Principal Investigator]); Columbus Children's Hospital, OH (Clinical center contributing cases) (Amanda Termuhlen, M.D. [Institutional Principal Investigator], Frederick Ruymann, M.D. [Former Institutional Principal Investigator], and Stephen Qualman, M.D. [Member of the CCSS Steering Committee]); Children's National Medical Center, Washington, D.C. (Clinical center contributing cases) (Gregory Reaman, M.D. [Institutional Principal Investigator] and Roger Packer, M.D. [Member of the CCSS Steering Committee]); Children's Hospital of Pittsburgh, PA (Clinical center contributing cases) (A. Kim Ritchey, M.D. [Institutional Principal Investigator] and Julie Blatt, M.D. [Member of the CCSS Steering Committee]); University of Minnesota, Minneapolis, MN (Clinical center contributing cases) (Leslie L. Robison, Ph.D. [Institutional Principal Investigator and Member of the CCSS Steering Committee], Ann Mertens, Ph.D. [Member of the CCSS Steering Committee], Joseph Neglia, M.D., M.P.H. [Former Institutional Principal Investigator], Mark Nesbit, M.D. [Member of the CCSS Steering Committee], and Stella Davies, M.D., Ph.D. [Member of the CCSS Steering Committee]); Children's Hospital of Los Angeles, CA (Clinical center contributing cases) (Kathy Ruccione, R.N., M.P.H. [Institutional Principal Investigator]); Memorial Sloan Kettering Cancer Center, New York (Clinical center contributing cases) (Charles Sklar, M.D. [Institutional Principal Investigator and Member of the CCSS Steering Committee]); National Cancer Institute, Bethesda, MD (Malcolm Smith, M.D. [Member of the CCSS Steering Committee] and Martha Linet, M.D. [Member of the CCSS Steering Committee]); Mayo Clinic, Rochester, MN (Clinical center contributing cases) (W. Anthony Smithson, M.D. [Institutional Principal Investigator] and Gerald Gilchrist, M.D. [Former Institutional Principal Investigator]); University of Texas M. D. Anderson Cancer Center, Houston, TX (Clinical center contributing cases) Louise Strong, M.D. [Institutional Principal Investigator] and Marilyn Stovall, Ph.D. [Member of the CCSS Steering Committee]); Riley Hospital for Children, Indianapolis, IN (Clinical center contributing cases) Terry A. Vik, M.D. [Institutional Principal Investigator] and Robert Weetman, M.D. [Former Institutional Principal Investigator]); Fred Hutchinson Cancer Center, Seattle, WA (Yukata Yasui, Ph.D. [Institutional Principal Investigator] and John Potter, M.D., Ph.D. [Former Institutional Principal Investigator and Member of the CCSS Steering Committee]); and University of California-Los Angeles, CA (Including Miller Children's Hospital, Long Beach and Children's Hospital of Orange County) (Clinical center contributing cases) (Lonnie Zeltzer, M.D. [Institutional Principal Investigator and Member of the CCSS Steering Committee]). Fax: (612) 625-0640 Funded by: National Cancer Institute, Bethesda, Maryland; Grant Number: CA 55727 Children's Cancer Research Fund, Minneapolis, Minnesota Abstract BACKGROUND The current study characterized the self-reported cancer screening practices of adult survivors of childhood cancer. METHODS A cohort of 9434 long-term survivors of childhood cancer and a comparison group of 2667 siblings completed a 289-item survey that included items regarding cancer-screening practices. RESULTS Overall, 27.3% of female respondents reported performing breast self-examination (BSE) regularly, 78.2% reported undergoing a Papanicolaou smear within the previous 3 years, 62.4% underwent a clinical breast examination (CBE) within the last year, and 20.9% had gotten a mammogram at least once in their lifetime. Approximately 17.4% of male respondents reported performing regular testicular self-examination (TSE). Women age 30 years who had been exposed to chest or mantle radiation therapy were more likely to report undergoing CBE (odds ratio [OR], 1.59; 95% confidence interval [95% CI], 1.32-1.92) and mammography (OR, 1.92; 95% CI, 1.47-2.56). Compared with the sibling comparison group, survivors demonstrated an increased likelihood of performing TSE (OR, 1.52; 95% CI, 1.22-1.85) or BSE (OR, 1.30; 95% CI, 1.10-1.52), of having undergone a CBE within the last year (OR, 1.18; 95% CI, 1.02-1.35), and of ever having undergone a mammogram (OR, 1.82; 95% CI, 1.52-2.17). CONCLUSIONS The results of the current study demonstrate that the cancer screening practices among survivors of childhood cancer are below optimal levels. Primary care physicians who include childhood cancer survivors among their patients could benefit these individuals by informing them about future cancer risks and recommending appropriate evidence-based screening. Cancer, 2/04 Volume 100, Issue 3 , Pages 631 - 640 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. 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