Schagen SB, van Dam FS, Muller MJ, Boogerd W, Lindeboom J, Bruning PF, "Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma." Cancer 1999 Feb 1;85(3):640-50 Conclusion: "Breast carcinoma patients treated with adjuvant CMF chemotherapy have a significantly higher risk of late cognitive impairment than breast carcinoma patients not treated with chemotherapy (OR 6.4). This cognitive impairment is unaffected by anxiety, depression, fatigue, and time since treatment, and not related to the self-reported complaints of cognitive dysfunction." Van Dam FSAM, Schagen SB, Muller M, et al. "Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapy." J Natl Cancer Inst 1998; 90: 210-18. Conclusion: "High-dose chemotherapy appears to impair cognitive functioning more than standard-dose chemotherapy. Central nervous system toxicity may be a dose-limiting factor in high-dose chemotherapy regimens. " Hjermstad MJ, Evensen SA, Kvaloy SO, Fayers PM, Kaasa S "Health-Related Quality of Life 1 Year After Allogeneic or Autologous Stem-Cell Transplantation: A Prospective Study." J Clin Oncol 17:706-718. This study looked at differing QOL aspects, and found that "cognitive function was the only scale with a statistically significant difference." KA Phillips, CB Brezden, M Abdolell, IF Tannock. "Cognitive Function in Breast Cancer Patients Receiving Standard-Dose Adjuvant Chemotherapy." Princess Margaret Hospital and University of Toronto. Proceedings of ASCO 1999. This study found that "Standard-dose adjuvant CT for BC may adversely affect cognitive function. If these findings are confirmed in future studies, it will be important to inform patients of this effect, and to investigate the potential mechanisms involved." Annals of Oncology, 8/02 The Breast, 4/05 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.