Pamidronate and 1,24(S)-dihydroxyvitamin D-2 [1,24(OH)(2)D-2] could inhibit the growth of myeloma, breast, and prostate cancer cells. According to a study from the United States, "Bisphosphonates have proven to be effective in the management of multiple myeloma and bone metastases secondary to breast and prostate carcinoma. Vitamin D compounds are important modulators of cellular proliferation and differentiation. 1,24(OH)(2)D-2 is a naturally occurring active vitamin D compound with high antiproliferative activity and low calcemic response. We examined the antiproliferative effects of 1,24(OH)(2)D-2 in combination with the bisphosphonate pamidronate on multiple myeloma (H929), prostate (LNCaP) and breast (MCF-7) cancer cell lines." "Drug-drug interactions were analyzed using the median-effect/isobologram method to characterize the interactions as synergistic, additive, or antagonistic. Pamidronate and 1,24(OH)(2)D-2 were found independently to inhibit cancer cell growth in a dose-dependent manner," discovered D.P. Wigington and colleagues, Bone Care International. The researchers concluded, "Combinations of these compounds produced marked synergistic growth-inhibitory effects at several clinically relevant concentrations. Combined dosing of pamidronate and 1,24(OH)(2)D-2 may have therapeutic value for the treatment of multiple myeloma, prostate, and breast cancers." Wigington and colleagues published their study in Anticancer Research (Pamidronate and 1,24(S)-dihydroxyvitamin D-2 synergistically inhibit the growth of myeloma, breast and prostate cancer cells. Anticancer Res, 2005;25(3B):1909-1917). For more information, contact D.P. Wigington, Bone Care International, 1600 Aspen Commons, Middleton, WI 53562, USA. Publisher contact information for the journal Anticancer Research is: International Institute Anticancer Research, Editorial Office 1ST km Kapandritiou-Kalamou Rd. Kapandriti, PO Box 22, Athens 19014, Greece. Source: NewsRx.com Our source: www.lef.org 08-19-05 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.