Vitamin C, Vitamin E, and Multivitamin Supplement Use and Stomach Cancer Mortality in the Cancer Prevention Study II Cohort Eric J. Jacobs1, Cari J. Connell, Marjorie L. McCullough, Ann Chao, Carolyn R. Jonas, Carmen Rodriguez, Eugenia E. Calle and Michael J. Thun Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia 30329-4251 Supplementation with antioxidant vitamins has been associated with decreased risk of stomach cancer or regression of precancerous lesions in high-risk areas of China and Colombia. We examined the association between stomach cancer mortality and regular use (15 times per month) of individual vitamin C supplements, individual vitamin E supplements, and multivitamins among 1,045,923 United States adults in the Cancer Prevention Study II (CPS-II) cohort. CPS-II participants completed a questionnaire at enrollment in 1982 and were followed for mortality through 1998. During follow-up, there were 1,725 stomach cancer deaths (1,127 in men and 598 in women). After adjustment for multiple potential stomach cancer risk factors, vitamin C use at enrollment was associated with reduced risk of stomach cancer mortality [rate ratio (RR), 0.83; 95% confidence interval (CI), 0.68–1.01]. However, this reduction in risk was observed only among participants with short duration use at enrollment (RR, 0.68; 95% CI, 0.51–0.91 for <10 years of use; RR, 1.00; 95% CI, 0.73–1.38 for 10 years of use). There was no association between stomach cancer mortality and regular use of vitamin E (RR, 1.02; 95% CI, 0.82–1.27) or multivitamins (RR, 0.89; 95% CI, 0.77–1.03), regardless of duration of use. Our results suggest that the use of vitamin C, vitamin E, or multivitamin supplements may not substantially reduce risk of stomach cancer mortality in North American populations in which stomach cancer rates are relatively low. Our results do not rule out effects of vitamin supplementation in areas in which stomach cancer rates are high and stomach cancer etiology may differ. Cancer Epidemiology Biomarkers & Prevention Vol. 11, 35-41, January 2002 © 2002 American Association for Cancer Research Ann's NOTE: We do not see information on the amount of any particular vitamin being taken. But I am quite sure the levels were not what we would now consider enough to make a difference. April-May 2005 Newsletter of Life Raft Group J Carcinogenesis, 11/06 Gastrointestinal Cancers Symposium, January 2008 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.