Epidemiology Vegetables, fruit and risk of gastric cancer in Japan: A 10-year follow-up of the JPHC study Cohort I Minatsu Kobayashi 1, Yoshitaka Tsubono 2, Shizuka Sasazuki 1, Satoshi Sasaki 1, Shoichiro Tsugane 1 *, JPHC Study Group 1Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Kashiwa, Japan 2Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University, Sendai, Japan email: Shoichiro Tsugane (stsugane@east.ncc.go.jp) *Correspondence to Shoichiro Tsugane, Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan Fax: +81-471-34-6862 The investigators and institutions participating in the JPHC Study Cohort I, a part of the JPHC Study Group, were as follows: S. Tsugane, S. Sasaki, Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Kashiwa; J. Ogata, S. Baba, National Center for Circulatory Diseases, Suita; K. Miyakawa, F. Saito, A. Koizumi, Iwate Prefectural Ninohe Public Health Center, Ninohe; Y. Miyajima, N. Suzuki, S. Nagasawa, Akita Prefectural Yokote Public Health Center, Yokote; H. Sanada, Y. Hatayama, F. Kobayashi, H. Uchino, Y. Shirai, T. Kondo, Nagano Prefectural Saku Public Health Center, Saku; Y. Kishimoto, E. Takara, M. Kinjo, T. Fukuyama, Okinawa Prefectural Ishikawa Public Health Center, Ishikawa; S. Matsushima, S. Natsukawa, Saku General Hospital, Usuda; S. Watanabe, M. Akabane, Tokyo University of Agriculture, Tokyo; M. Konishi, Ehime University, Matsuyama; S. Tominaga, Aichi Cancer Center Research Institute, Nagoya; M. Iida, S. Sato, Center for Adult Diseases, Osaka; the late M. Yamaguchi, Y. Matsumura, National Institute of Health and Nutrition, Tokyo; Y. Tsubono, Tohoku University, Sendai; H. Iso, Tsukuba University, Tsukuba; H. Sugimura, Hamamatsu University, Hamamatsu; M. Kabuto, National Institute for Environmental Studies. Abstract The association between vegetables and fruit consumption and gastric cancer risk was investigated in a population-based prospective study in 4 public health center areas in Japan. Dietary and other exposure data were obtained in 1990 from a cohort of 19,304 men and 20,689 women with a self-administered questionnaire. After 10 years of follow-up, a total of 404 cases of gastric cancer were documented among them. After adjustment for age, gender, areas and other potential confounding factors and after exclusion of the cases diagnosed in first and second follow-up years, the relative risk associated with intake 1 or more days per week compared to less than 1 day per week was 0.64 (95% CI 0.45-0.92) for yellow vegetable, 0.48 (95% CI 0.25-0.89) for white vegetable and 0.70 (95% CI 0.49-1.00) for fruit. Relative risks associated with quintile of total vegetable consumption were 1.00, 0.86, 0.75, 0.90 and 0.75 (p for trend = 0.17). In the differentiated type of gastric cancer, the association became clearer: 1.00, 0.96, 0.78, 0.88 and 0.53 (p for trend = 0.03). This prospective study suggests that vegetable and fruit intake, even in low amounts, is associated with a lower risk of gastric cancer. Although no striking differences in the association were seen between cardia and noncardia cancer, an inverse association was higher in differentiated rather than in undifferentiated types of gastric cancer International J Cancer, 102, Issue 1 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.